About CAR-T Technology

CAR-T cell immune-therapies may completely change the reality of cancer treatment

The core mechanism of CAR-T therapy is enabling the effector T cell to identify specific tumor antigens by adding tumor antigen receptor to T cell, resulting in prolonged and drastic increase of targeted killing of tumor cells and to overcome host immune tolerance and immune escape.

• Relatively more safe

 

It is widely proved to be a safe and effective

biotherapy

 

• Better targeting and higher specificity

 

Pinpoint elimination of tumor cell to avoid

damaging normal cells

 

• Improved clinical results

 

90% effective rate， over 60% cure rate

 

• Less adverse reactions

 

The least side effects of current anti-cancer

therapies clinically available

• OFF-TARGET EFFECT       May causes severe autoimmune reaction of normal tissue.

  CYTOKINE STORM

        large amount of TNF-α, IL-1, 6, 8, 12, IFN-α, β, γ, MCP-1 etc. released into

        the system can cause respiratory distress syndrome, multiple organ failure

        and cerebral edema.

  INSERTION MUTATION

        Insertion of foreign DNA fragment disrupted original gene structure causing

        “insertion mutation”. The long term stay or circulation of mutated T cell

         theoretically caries tumorigenesis risks.